2-4-5 Trioxin Leaking out of canister

Trioxin (a.k.a. 2-4-5 Trioxin) is a chemical agent that has been the subject of a few Zombie-centred documentaries.


Trioxin is a yellow or greenish vapor (caused by sulfurism) which makes the skin feel as though it were burning, due to the toxicity of the chemical causing nerve endings to fire at random. It has been known to be typically stored under extreme pressure in large steel drums, secured by code-protected locking mechanisms. It was originally developed by the Darrow Chemical Company for the United States military as a herbicide to be used for destroying illegal marijuana plants; however, it was discovered to possess rejuvenating properties after a large quantity of the chemical was accidentally released into a nearby morgue, causing the cadavers to reanimate. The toxin facilitates reanimating right down to the cellular level, meaning that dismembered body parts or even skeletons possessed only of connective tissue could reanimate, and stay reanimated, regardless of their condition. Moreover, trioxin appears to be extremely toxic, and a single exposure to a concentrated amount can both kill a person and revive them.

Zombies created by exposure to trioxin retain all of their former intelligence and athletic capabilities, including the ability to speak, run, and climb. Human behaviors and emotions fade as the brain shuts down, however, leaving only the base instinct to feed. Like normal cadavers, they suffer the effects of rigor mortis. They also crave human brains; one zombie explains that this is because the bio-electricity in brains can stave off the pain of decomposition. Unlike other zombies, the only known ways to destroy zombies created by trioxin are by incineration or electrocution. Attempts to destroy the brain or even completely dismember a trioxin zombie have invariably failed.

Though a volatile gas, 2-4-5 Trioxin is fairly stable, and can withstand temperatures in the thousands of degrees. Attempts to cremate trioxin-spawned zombies typically release trioxin gas into the air, where it may contaminate rainclouds. The resulting rainfall is irritating to the skin, which often leads victims to assume that it is acid rain. This "Trioxin shower" is no longer concentrated enough to kill a human outright, but if the contaminated rainwater falls on a location housing corpses, such as a cemetery, it can potentially reanimate every corpse interred there.

According to the Return of the Living Dead series, trioxin was the cause of an incident on which the movie Night of the Living Dead was based. The incident states that at some point in the 60's, 2-4-5 Trioxin was spilled and seeped into a VA morgue. Since the zombies created by Trioxin could not be killed with a shot to the head, unlike the zombies in the film, they were stored in sealed drums for over two decades. In Return of the Living Dead III, it is revealed that the U.S. military is deliberately experimenting with trioxin in an effort to create zombie supersoldiers. This is further explored in Return of the Living Dead: Necropolis, where most of the plot takes place in a lab designed for that very purpose.

In Return of the Living Dead: Necropolis and Return of the Living Dead 5: Rave from the Grave, the chemical is referred to simply as Trioxin 5. This is perhaps purposeful, as in the aforementioned films the reanimated act rather differently than in the first 3 parts, and are easily killed through the traditional head-shot (a la George A. Romero zombies) possibly indicating that a new version of Trioxin was developed specifically in order to be able to destroy the zombies it creates in the event they get out of control.

Any one who comes into contact with an infected human must and should contact their center for disease control as soon as possible. You may experience fever-like symptoms accompanied by hypoxia (swelling of the larynx, sweating, clammy skin) and/or dizziness. Kaiser Permanente has known about this for years. However, They've been ignored in the general community.

Real world basis

The concept of 2-4-5 Trioxin is based in part on Agent Orange, a real-life defoliant used by the Army during the Vietnam War. The two chemicals share a number of similarities: both were used against plants by the United States Army during the 1960s, and both proved to have horrifying side effects. One of the two chemicals used to produce Agent Orange is called 2,4,5-Trichlorophenoxyacetic acid. Agent Orange also contained chemicals known as dioxins.

2-4-5 Trioxin should not be mistaken for the real chemical trioxane, which is used by morticians to repair cells and maintain a corpse's contours after postmortem tissue constriction.

Trioxin in music

  • Trioxin Inc.[1] (parent company of Trioxin Records and Trioxin Productions) is the Houston-based music label consisting of the group S.H.S.M.[2] as their flagship rap group.
  • Trioxin 245 is a hard rock band from Canada.
  • 2-4-5 Trioxin is the name of an Indianapolis, Indiana-based punk band.
  • Trioxin is also a song by death/gore metal band Lord Gore.
  • Trioxin 245 is featured in the Send More Paramedics video 'Blood Fever'.
  • 'Trioxin' is the name of a thrash metal band from Kristiansand, Norway, formed in 2003.
  • "Trioxin" is the name of a horror punk band in San Antonio, Texas.
  • "Trioxin" is the name of a song by the Flordia based trio Zombies! Organize!!
  • Trioxin Cherry is the name of a band in Nottingham, UK.
  • Appears in a God Module song titled "Brainz"
  • "Trioxin 245" is the name of a song and album by drum and bass artist Corrupt Souls
  • "Trioxin" - song by The Ranger (Nerdcore artist, AU) released on a RhymeTorrents.org (Nerdcore Hip-Hop Forum) Holloween 3.0 compilation.
  • "Trioxin"- song by A britsh groove metal band based in Stamford linc's Flawless Victory
  • "Trioxin (Instru-Mental)" - is featured on the 2-Disc, limited edition of Zombie Girl's Blood, Brains & Rock 'N' Roll
  • "Trioxin245" is the name of a mix CD released by DJ DEPATH & M-Project in 2006
  • "Trioxin 2-4-5" is the name of the first track from the EP "Through the Eyes of the Dead" by the Melbourne based Australian metal group, Witchgrinder, released in May 2010.
  • Horror Punk band Mister Monster's lead singer's stage name is J-Sin Trioxin.
  • "245 Trioxin" is the name of the first track from the CD "...Occuring before in time..." by the instrumental Metal band "Kings Of Prussia" from Asheville, North Carolina.
  • "Trioxin 2-4-5" is the name of a song in the album "The war inside" by Alchemy of Death'
  • 2-4-5 Trioxin is mentioned in the song "HMH3: Do The Zombie" on the 2010 release "Score" by The Jolly Rogers.

Trioxin in other popular culture

  • In the Star Trek: Voyager episode, "Year of Hell, Part 2," Captain Janeway demands that the doctor inject her with "Trioxin," as emergency treatment for lung damage. This is likely the name of the 'tri-ox compound' referred to in the Original Series episode "Amok Time".
  • In GUNNM: Last Order Vol. 11 Trioxin 245 is mentioned as one of the five most destructive weapons ever to be developed by human kind.
  • In the webcomic [Erfworld], a Master-Class Croakamancer (a mage who deals in reanimation of the dead) stands before a thousand dead bodies and invokes the spell "Trioxin" to reainmate them all, in an obvious nod to NotLD.